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Clinical Trial
. 2008 Sep;29(9):894-7.
doi: 10.1086/590192.

Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia

Saima Aslam  1 , Barbara W Trautner, Venkat Ramanathan, Rabih O Darouiche
Affiliations
Clinical Trial

Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia

Saima Aslam et al. Infect Control Hosp Epidemiol. 2008 Sep.

Abstract

We evaluated a catheter-lock solution consisting of N-acetylcysteine, tigecycline, and heparin for catheter salvage in patients with hemodialysis catheter-associated bacteremia. Eighteen case patients received the catheter-lock solution for 14 days plus systemic antibiotic therapy. Treatment was successful for 15 (83%) of the 18 case patients within 90 days of follow-up, with a median catheter retention interval of 64.5 days.

Trial registration: ClinicalTrials.gov NCT00614679.

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