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. 2008 Sep;159(4):881-6.
doi: 10.1111/j.1365-2133.2008.08761.x. Epub 2008 Jul 17.

The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality

C Massone  1 , G Crisman, H Kerl, L Cerroni
Affiliations

The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality

C Massone et al. Br J Dermatol. 2008 Sep.

Abstract

Background: The influence of phenotype and detection of clonality on prognosis in early mycosis fungoides has never been addressed in large studies.

Objectives: To correlate immunophenotype and detection of clonality with clinical outcome.

Methods: We analysed 73 biopsy specimens from 68 patients with early mycosis fungoides (stage Ia or Ib) and at least 10 years of follow up (or dead of disease).

Results: Four phenotypic groups could be identified: group A (alpha/beta+ CD4+ CD8- TIA1-), 51 patients; median survival time 160 months; group B (alpha/beta+ CD4- CD8+ TIA1+), 10 patients; median survival time 195 months; group C (alpha/beta- CD4- CD8+/- TIA1+), five patients; median survival time 165 months; and group D (alpha/beta+ CD4- CD8- TIA1-), two patients; median survival time 130 months. Survival curves did not show statistical differences among the groups. Monoclonality was detected in 36 of 67 tested biopsies (54%), and statistical analyses did not show prognostic differences between the clonal and nonclonal cases.

Conclusions: We conclude that cytotoxic phenotype and detection of monoclonal T-cell receptor-gamma gene rearrangement in early lesions of mycosis fungoides do not have any prognostic significance.

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