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Review
. 2008 Jul 27;86(2):192-9.
doi: 10.1097/TP.0b013e31817eef7b.

Noninvasive prediction of organ graft rejection and outcome using gene expression patterns

Dany Anglicheau  1 , Manikkam Suthanthiran
Affiliations
Review

Noninvasive prediction of organ graft rejection and outcome using gene expression patterns

Dany Anglicheau et al. Transplantation. .

Abstract

Development of predictive, diagnostic, and prognostic biomarkers of allograft status and outcome is important and challenging, and may be rewarded with individualized therapy for the organ graft recipient. Herein, we summarize noninvasive messenger RNA profiling studies for ascertaining allograft status and outcome. Nucleic acid-based biomarkers of allograft status have been developed by several laboratories, but the studies have primarily been single center investigations. Ongoing multicenter trials including the Clinical Trials in Organ Transplantation (https://www.ctotstudies.org) should help further to define the clinical utility of noninvasively developed messenger RNA profiles as biomarkers of allograft status and outcome.

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Conflict of interest statement

Conflict of interest statement: DA has no conflicts of interest related to this study. A US patent entitled “Methods of Evaluating Transplant Rejection” (6187534) was issued on February 13, 2001; Dr. Suthanthiran is a one of the inventors. The patent is owned jointly by Harvard Medical School, Cornell University, and the Beth Israel-Deaconess Medical Center, Boston.

Figures

Figure 1
Figure 1. A Time-Line Model for Allograft Rejection
In this formulation, rejection defined by molecular markers precedes histologically defined rejection and this precedes clinically defined rejection. The hypothesis that early intervention is highly efficacious is an important rationale for the development of molecular surveillance strategies to anticipate histologic and clinical rejection.
See this image and copyright information in PMC

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