Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1991 Jul;87(3):290-6.
doi: 10.1007/BF00200906.

Characterization of seven DA/DAPI-positive bisatellited marker chromosomes by in situ hybridization

R Plattner  1 , N A Heerema, S R Patil, P N Howard-Peebles, C G Palmer
Affiliations
Case Reports

Characterization of seven DA/DAPI-positive bisatellited marker chromosomes by in situ hybridization

R Plattner et al. Hum Genet. 1991 Jul.

Abstract

Seven dicentric bisatellited marker chromosomes, ascertained at amniocentesis, chorionic villus sampling, and in blood from an abnormal liveborn were characterized cytogenetically. All seven markers demonstrated brilliant bands by the DA/DAPI technique corresponding to C-band positive regions. Although some dicentric DA/DAPI-positive bisatellited markers have been identified as inverted duplicated 15s, recent literature has suggested that DA/DAPI lacks specificity for chromosome 15. Our evaluation of DA/DAPI-positive bisatellited marker chromosomes by in situ hybridization shows that some originate from chromosome 15 whereas DA/DAPI negative bisatellited markers may not be derived from 15. The morphological variations noted in our studies are discussed with respect to nomenclature.

PubMed Disclaimer

References

    1. Hum Genet. 1986 Aug;73(4):298-300 - PubMed
    1. Cytogenet Cell Genet. 1987;45(1):62 - PubMed
    1. Chromosoma. 1985;93(1):77-86 - PubMed
    1. J Immunol Methods. 1981;43(3):349-50 - PubMed
    1. Clin Genet. 1980 Jul;18(1):42-7 - PubMed

Publication types