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. 2008 Nov 29;27(27):5578-85.
doi: 10.1002/sim.3383.

Sample size calculation for cluster randomized cross-over trials

B Giraudeau  1 , P Ravaud, A Donner
Affiliations

Sample size calculation for cluster randomized cross-over trials

B Giraudeau et al. Stat Med. .

Erratum in

  • Stat Med. 2009 Feb 15;28(4):720

Abstract

The cluster randomized cross-over design has been proposed in particular because it prevents an imbalance that may bring into question the internal validity of parallel group cluster trials. We derived a sample size formula for continuous outcomes that takes into account both the intraclass correlation coefficient (representing the clustering effect) and the interperiod correlation (induced by the cross-over design).

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