doi: 10.1016/s0021-9673(00)84036-4.
Quantitative high-performance liquid chromatography of diazepam and N-desmethyldiazepam in blood
- PMID: 186471
- DOI: 10.1016/s0021-9673(00)84036-4
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Quantitative high-performance liquid chromatography of diazepam and N-desmethyldiazepam in blood
J Chromatogr.
.
Abstract
High-performance liquid chromatography on porous silica has been employed to determine diazepam and N-desmethyldiazepam in human blood. For forensic purposes, 1.0 ml of blood is sufficient for a quantitative determination of the benzodiazepines in concentrations above 100 ng/ml. In cases where lower levels, 25-100 ng/ml, are of interest, 2.0 ml of blood together with a somewhat more elaborate extraction procedure are necessary.
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