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. 1976 Nov 17;128(1):111-6.
doi: 10.1016/s0021-9673(00)84036-4.

Quantitative high-performance liquid chromatography of diazepam and N-desmethyldiazepam in blood

A Bugge

Quantitative high-performance liquid chromatography of diazepam and N-desmethyldiazepam in blood

A Bugge. J Chromatogr. .

Abstract

High-performance liquid chromatography on porous silica has been employed to determine diazepam and N-desmethyldiazepam in human blood. For forensic purposes, 1.0 ml of blood is sufficient for a quantitative determination of the benzodiazepines in concentrations above 100 ng/ml. In cases where lower levels, 25-100 ng/ml, are of interest, 2.0 ml of blood together with a somewhat more elaborate extraction procedure are necessary.

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