Review
doi: 10.1387/ijdb.082696hf.
Regulating the acrosome reaction
Affiliations
- PMID: 18649263
- DOI: 10.1387/ijdb.082696hf
Item in Clipboard
Review
Regulating the acrosome reaction
Int J Dev Biol.
2008.
Free article
Abstract
The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in triggered by ZP3, a glycoprotein component of the egg pellucida, following gamete contact. ZP3 promotes a sustained influx of Ca2+ into sperm that is necessary for the acrosome reaction. Here, we discuss the mechanism by which ZP3 generates Ca2+ entry, as well as the upstream events leading to this influx and downstream processes that couple it with exocytosis.
Similar articles
-
Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3.Nat Cell Biol. 2001 May;3(5):499-502. doi: 10.1038/35074570. Nat Cell Biol. 2001. PMID: 11331878
-
Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction.Mol Biol Cell. 2000 May;11(5):1571-84. doi: 10.1091/mbc.11.5.1571. Mol Biol Cell. 2000. PMID: 10793136 Free PMC article.
-
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein.Science. 2010 Jul 9;329(5988):216-9. doi: 10.1126/science.1188178. Science. 2010. PMID: 20616279 Free PMC article.
-
Identification of novel gamete receptors that mediate sperm adhesion to the egg coat.Mol Cell Endocrinol. 2006 May 16;250(1-2):137-48. doi: 10.1016/j.mce.2005.12.037. Epub 2006 Jan 18. Mol Cell Endocrinol. 2006. PMID: 16417965 Review.
-
Sperm receptors and fertilization in mammals.Mt Sinai J Med. 2002 May;69(3):148-55. Mt Sinai J Med. 2002. PMID: 12035074 Review.
Cited by
-
CatSper and its CaM-like Ca2+ sensor EFCAB9 are necessary for the path chirality of sperm.FASEB J. 2022 May;36(5):e22288. doi: 10.1096/fj.202101656RR. FASEB J. 2022. PMID: 35438819 Free PMC article.
-
Mouse models in male fertility research.Asian J Androl. 2011 Jan;13(1):139-51. doi: 10.1038/aja.2010.101. Epub 2010 Nov 8. Asian J Androl. 2011. PMID: 21057516 Free PMC article. Review.
-
Rediscovering sperm ion channels with the patch-clamp technique.Mol Hum Reprod. 2011 Aug;17(8):478-99. doi: 10.1093/molehr/gar044. Epub 2011 Jun 4. Mol Hum Reprod. 2011. PMID: 21642646 Free PMC article. Review.
-
The Catsper channel and its roles in male fertility: a systematic review.Reprod Biol Endocrinol. 2017 Aug 15;15(1):65. doi: 10.1186/s12958-017-0281-2. Reprod Biol Endocrinol. 2017. PMID: 28810916 Free PMC article.
-
Role and regulation of EGFR in actin remodeling in sperm capacitation and the acrosome reaction.Asian J Androl. 2011 Jan;13(1):106-10. doi: 10.1038/aja.2010.78. Epub 2010 Oct 18. Asian J Androl. 2011. PMID: 21200378 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
