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Comment
. 2008 Jul 29;105(30):10277-8.
doi: 10.1073/pnas.0805458105. Epub 2008 Jul 23.

The contrasting role of B7-H3

Kimberly A Hofmeyer  1 , Anjana Ray, Xingxing Zang
Affiliations
Comment

The contrasting role of B7-H3

Kimberly A Hofmeyer et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
B7-H3 acts through T cell costimulation and coinhibition and beyond. Phylogenetic tree of the B7 family generated by PAUP (2, 3). This analysis divides the B7 family into three groups. B7-H3 is broadly expressed. It binds to TLT-2 and costimulates T cell activation, whereas binding to unidentified receptor(s) leads to coinhibition of T cells. In addition, B7-H3 is an inhibitor for NK cells and osteoblastic cells by ligating unknown receptor(s).
See this image and copyright information in PMC

Comment on

References

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