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. 2009 Jan;129(1):246-8.
doi: 10.1038/jid.2008.229. Epub 2008 Jul 24.

Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors

Kelly M Garneski, Ashley H Warcola, Qinghua Feng, Nancy B Kiviat, J Helen Leonard, Paul Nghiem

Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors

Kelly M Garneski et al. J Invest Dermatol. 2009 Jan.
No abstract available

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Conflict of interest statement

CONFLICT OF INTEREST

The authors state no conflict of interest.

Figures

Figure 1
Figure 1. Presence of MCPyV DNA in samples from North America (NA) and Australia (AU)
MCC – Merkel cell carcinoma, SCC – squamous cell carcinoma, Skin – UV-exposed skin from age and sex matched controls. P-values calculated using Fisher’s exact test.
Figure 2
Figure 2. Marked variability of Merkel cell polyomavirus DNA quantity among MCC tumors
The amount of MCPyV DNA was compared to the amount of DNA of a control gene on chromosome 2 (TPO). Note the wide range in levels of MCPyV DNA. MCC primaries (n=8, circles), recurrences (n=13, squares), nodal metastases (n=15, triangles), and distant metastases (n=1, diamond) are compared. Also shown are squamous cell carcinomas (ovals) and sun-exposed skin controls (pentagons). Tumors originating from North America are represented with closed symbols and those originating from Australia are represented with open symbols. Tumors represented as not detected had good amplification of control gene but no detectable MCPyV by both primer sets.
See this image and copyright information in PMC

Comment in

References

    1. Engels EA, Frisch M, Goedert JJ, Biggar RJ, Miller RW. Merkel cell carcinoma and HIV infection. Lancet. 2002;359:497–498. - PubMed
    1. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319:1096–1100. - PMC - PubMed
    1. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Penas PF, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol. 2008;58:375–381. - PMC - PubMed
    1. Miller RW, Rabkin CS. Merkel cell carcinoma and melanoma: etiological similarities and differences. Cancer Epidemiol Biomarkers Prev. 1999;8:153–158. - PubMed
    1. Van Gele M, Speleman F, Vandesompele J, Van Roy N, Leonard JH. Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization. Cancer Res. 1998;58:1503–1508. - PubMed

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