Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jul 25;321(5888):532-4.
doi: 10.1126/science.1160355.

Whither or wither microbicides?

Robert M Grant  1 , Dean Hamer, Thomas Hope, Rowena Johnston, Joep Lange, Michael M Lederman, Judy Lieberman, Christopher J Miller, John P Moore, Donald E Mosier, Douglas D Richman, Robert T Schooley, Marty S Springer, Ronald S Veazey, Mark A Wainberg
Affiliations

Whither or wither microbicides?

Robert M Grant et al. Science. .

Abstract

After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination among interested parties and the choice of nonvalidated scientific targets for phase III studies have hampered progress and created mistrust about the use of microbicides as a method to prevent HIV-1 sexual transmission. Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical.

PubMed Disclaimer

References

    1. Microbicides Development Programme Update. www.mdp.mrc.ac.uk/downloads/MDP_statement_14Feb08_v1[1].2_FINAL.pdf.
    1. van de Wijgert JH, Shattock RJ. AIDS. 2007;21:2369. - PubMed
    1. Hillier SL, et al. J Acquir Immune Defic Syndr. 2005;39:1. - PubMed
    1. Feldblum PJ, et al. PLoS One. 2008;3:e1474. - PMC - PubMed
    1. Moulard M, et al. J Virol. 2000;74:1948. - PMC - PubMed

MeSH terms