doi: 10.1016/j.bmcl.2008.07.027.
Epub 2008 Jul 15.
A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis
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- PMID: 18656351
- DOI: 10.1016/j.bmcl.2008.07.027
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A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis
Bioorg Med Chem Lett.
.
Abstract
A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
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