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. 2008 Aug 15;18(16):4593-6.
doi: 10.1016/j.bmcl.2008.07.027. Epub 2008 Jul 15.

A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis

Jian-Chiou Su  1 , Chin-Lu Tseng, Ting-Gung Chang, Wen-Jen Yu, Shih-Kwang Wu
Affiliations

A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis

Jian-Chiou Su et al. Bioorg Med Chem Lett. .

Abstract

A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.

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