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. 2008 Jul;10(8):922-7.
doi: 10.1016/j.micinf.2008.05.001. Epub 2008 May 14.

A murine intraperitoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent

Olivia L Champion  1 , Yanet Valdez, Lisa Thorson, Julian A Guttman, Alfredo Menendez, Erin C Gaynor, B Brett Finlay
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Free article

A murine intraperitoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent

Olivia L Champion et al. Microbes Infect. 2008 Jul.
Free article

Abstract

We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp1 dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in Nramp1+/+ mice 4 days post-infection (PI) (liver) and 8 days PI cecum-colon. In contrast, Nramp1-/- mice showed no significant reduction of C. jejuni and instead had a chronic inflammatory response and significant histopathological lesions 30 days PI. Differential cytokine profiles were observed in C. jejuni infected Nramp1+/+ and Nramp1-/- primary dendritic cells. Taken together these data indicate that Nramp1 is critical for host resistance to C. jejuni.

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