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Review
. 2008 Oct;13(19-20):882-7.
doi: 10.1016/j.drudis.2008.06.016. Epub 2008 Aug 7.

Virus-sized vaccine delivery systems

Jean-Pierre Y Scheerlinck  1 , Deanne L V Greenwood
Affiliations
Review

Virus-sized vaccine delivery systems

Jean-Pierre Y Scheerlinck et al. Drug Discov Today. 2008 Oct.

Abstract

In a return to the early days of vaccine development during which effective vaccines were produced against viruses, virus-sized vaccine delivery systems have made a comeback. Using modern production technologies these nanoparticles have proved to be very effective at inducing cellular and humoral immune responses. Here, we review a number of vaccine delivery systems based on nanoparticles in the size range of typical viruses. Different strategies for generating these particles, ranging from recombinant virus-like particles to inert nanobeads via ISCOMs and nanoparticle-based DNA vaccine delivery systems, are discussed. In addition, possible mechanisms of immune induction are explored.

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