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. 2008 Sep 4;10(17):3729-32.
doi: 10.1021/ol801230k. Epub 2008 Jul 26.

Triazole-linked analogue of deoxyribonucleic acid ((TL)DNA): design, synthesis, and double-strand formation with natural DNA

Hiroyuki Isobe  1 , Tomoko Fujino, Naomi Yamazaki, Marine Guillot-Nieckowski, Eiichi Nakamura
Affiliations

Triazole-linked analogue of deoxyribonucleic acid ((TL)DNA): design, synthesis, and double-strand formation with natural DNA

Hiroyuki Isobe et al. Org Lett. .

Abstract

A new triazole-linked analogue of DNA ((TL)DNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA.

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