Review
doi: 10.1161/ATVBAHA.108.172015.
Epub 2008 Jul 24.
Integrins: the keys to unlocking angiogenesis
Affiliations
- PMID: 18658045
- DOI: 10.1161/ATVBAHA.108.172015
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Review
Integrins: the keys to unlocking angiogenesis
Arterioscler Thromb Vasc Biol.
2008 Oct.
Abstract
Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them potential targets for antiangiogenic therapy. Here we review the contribution of endothelial and mural cell integrins to angiogenesis and highlight their potential as antiangiogenesis targets.
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