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Randomized Controlled Trial
. 2008 May-Jun;74(3):337-41.
doi: 10.1016/s1808-8694(15)30565-6.

Antibiotic use in post-adenotonsillectomy morbidity: a randomized prospective study

Marja Michelin Guerra  1 , Eduardo Garcia, Renata Ribeiro de Mendonça Pilan, Priscila Bogar Rapoport, Caio Barbosa Campanholo, Eli Onivaldo Martinelli
Affiliations
Randomized Controlled Trial

Antibiotic use in post-adenotonsillectomy morbidity: a randomized prospective study

Marja Michelin Guerra et al. Braz J Otorhinolaryngol. 2008 May-Jun.

Abstract

Tonsillectomy with or without adenoidectomy still is one of the most commonly performed surgical procedures in the world, mostly in the pediatric population.

Aim: to study the impact of amoxicillin for 7 days in post-adenotonsillectomy recovery, comparing results with a control group.

Study type: prospective, randomized, controlled study with 120 patients.

Patients and methods: the patients were randomized according to surgery time to receive 7 days of amoxicillin associated with pain killers, or analgesic alone. During the first week of postoperative, we assessed the level of pain, oral intake acceptance, nausea and vomits, fever and return to daily activities.

Results: It was only in the fourth post-operative day that the group receiving antibiotic agents showed a statistically significant difference as far as pain is concerned. There was no difference between the two groups for other data analyzed.

Conclusion: considering the results from our study and reviewing the literature on the use of antibiotic agents, we agree that there is no improvement in patient recovery after adenotonsillectomy with the use of amoxicillin for 7 days in the postoperative.

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Figures

Figure 1
Figure 1
PAIN - Comparative chart - prevalence of pain between groups
Figure 2
Figure 2
USE OF DIPYRONE TO MANAGE PAIN - GROUP 1 - 79% of the patients in group 1 required analgesia with dipyrone. Analgesics were mostly required by the second day of post-op and were administered to 23.3% of the patients
Figure 3
Figure 3
USE OF DIPYRONE TO MANAGE PAIN - GROUP 2 - 88% of the patients in group 2 required analgesics to manage their pain. Analgesics were mostly required by the third day of post-op and were administered to 21% of the patients.
Figure 4
Figure 4
FEVER IN THE GROUP TREATED WITH ANTIBIOTICS - twenty-two patients (51.2%) in group 1 had fever in the post-op.
Figure 5
Figure 5
FEVER IN THE CONTROL GROUP - 26.9 patients (51.9%) in group 2 had fever in the post-op.
Figure 6
Figure 6
BLEEDING - incidence of post-op bleeding in the groups. No cases of primary bleeding were reported.
See this image and copyright information in PMC

References

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    1. Jones J, Handler SD, Guttenplan M, Potsic W, Weltmore R, Tom LWC, Marsh R. The Efficacy of Cefaclor vs Amoxicillin on Recovery After Tonsillectomy in Chindren. Arch Otolaryngol Head Neck Surg. 1990;116:590–593. - PubMed
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    1. Telian SA, Handler SD, Fleisher GR, Baranak CC, Weltmore RF, Potsic WP. The Effect of Antibiotic Therapy on Recovery After Tonsillectomy in Children. Arch Otolaryngol Head Neck Surg. 1986;112:610–615. - PubMed
    1. Al-Kindy SA. Do antibiotics decrease post-tonsillectomy morbidity? Saudi Med J. 2002;23:705–707. - PubMed

Uncited Reference

    1. Ranjit S, Brett RH, Lu PKS, Aw CY. The incidence and management of post-tonsilectomy haemorrhage: a Singaporean experience. Singapore Med J. 1999;40:622–626. - PubMed

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