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. 2008 May-Jun;74(3):356-9.
doi: 10.1016/s1808-8694(15)30568-1.

nm23 protein expression in metastatic and non-metastatic tongue squamous cell carcinoma

Ericka Janine Dantas da Silveira  1 , Márcio Campos Oliveira, Maria de Lourdes Silva Arruda de Morais, Lélia Maria Guedes Queiroz, Antonio de Lisboa Lopes Lopes Costa
Affiliations

nm23 protein expression in metastatic and non-metastatic tongue squamous cell carcinoma

Ericka Janine Dantas da Silveira et al. Braz J Otorhinolaryngol. 2008 May-Jun.

Abstract

Oral squamous cells carcinoma (OSCC) shows unfavorable prognosis due to its invasion potential around the neighboring tissues and the elevated incidence of metastasis.

Aim: the present paper aims at analyzing the immunohistochemical expression of the nm23 protein in metastatic and non-metastatic SCCs of tongue.

Methods: the immuno-expression to the nm23-hl protein was diagnosed in 35 tongue SCC (15 of which exhibiting metastasis). Nm23-hl immuno-scores were assigned as follow: score 0 = absent, 1 = focal and 2 = diffuse expression.

Results: The Fisher's exact test was performed and there was no statistical difference between the nm23-hl immuno-scores and the tongue SCCs studied cases (p=0.365), although 66.7% of metastatic cases presented negative nm23-hl expression.

Conclusions: Protein nm23 was not associated with a positiveness for tongue SCC without metastasis. Thus, several others factors inherent to host and malignancy can be associated with the mechanisms that suppress the metastatic process in this disease.

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Figures

Figure 1
Figure 1
Immunohistochemical expression of the nm23-h1 protein in the cytoplasm of cells in the neoplastic squamous cell carcinoma of the tongue.
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