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Randomized Controlled Trial
. 2008 Jul 28;168(14):1550-9; discussion 1559-60.
doi: 10.1001/archinte.168.14.1550.

Effect of exercise on 24-month weight loss maintenance in overweight women

John M Jakicic  1 , Bess H Marcus, Wei Lang, Carol Janney
Affiliations
Randomized Controlled Trial

Effect of exercise on 24-month weight loss maintenance in overweight women

John M Jakicic et al. Arch Intern Med. .

Erratum in

  • Arch Intern Med. 2008 Oct 27;168(19):2162

Abstract

Background: Debate remains regarding the amount of physical activity that will facilitate weight loss maintenance.

Methods: Between December 1, 1999, and January 31, 2003, 201 overweight and obese women (body mass index [calculated as weight in kilograms divided by height in meters squared], 27 to 40; age range, 21-45 years) with no contraindications to weight loss or physical activity were recruited from a hospital-based weight loss research center. Participants were assigned to 1 of 4 behavioral weight loss intervention groups. They were randomly assigned to groups based on physical activity energy expenditure (1000 vs 2000 kcal/wk) and intensity (moderate vs vigorous). Participants also were told to reduce intake to 1200 to 1500 kcal/d. A combination of in-person conversations and telephone calls were conducted during the 24-month study period.

Results: Weight loss did not differ among the randomized groups at 6 months' (8%-10% of initial body weight) or 24 months' (5% of initial body weight) follow-up. Post-hoc analysis showed that individuals sustaining a loss of 10% or more of initial body weight at 24 months reported performing more physical activity (1835 kcal/wk or 275 min/wk) compared with those sustaining a weight loss of less than 10% of initial body weight (P < .001).

Conclusions: The addition of 275 mins/wk of physical activity, in combination with a reduction in energy intake, is important in allowing overweight women to sustain a weight loss of more than 10%. Interventions to facilitate this level of physical activity are needed.

Trial registration: ClinicalTrials.gov NCT00006315.

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Figures

Figure 1
Figure 1
Flow chart of subject randomization and follow-up.
Figure 2
Figure 2
Percent weight loss based on randomized group assignment (N = 191).
Figure 3
Figure 3
Figure 3a. Physical activity (0, 6, and 24 months) for categories of 24-month weight loss (N = 170). Figure 3b. Physical activity (0, 6, 12, 18, and 24 months) for categories of 24-month weight loss (N = 81).
Figure 3
Figure 3
Figure 3a. Physical activity (0, 6, and 24 months) for categories of 24-month weight loss (N = 170). Figure 3b. Physical activity (0, 6, 12, 18, and 24 months) for categories of 24-month weight loss (N = 81).
Figure 4
Figure 4
Percent Weight Loss for Categories of 24-Month Physical Activity (min/wk) (N=170).
Figure 5
Figure 5
Percent Weight Loss for Categories of 24-month Physical Activity (kcal/wk) (N = 170).
See this image and copyright information in PMC

Comment in

References

    1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295(13):1549–1555. - PubMed
    1. Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophsiology, evaluation, and effect of weight loss. An update of the 1997 American Heart Assocation Scientific Statement of Obesity and Heart Disease from the Obesity Committee on the Council of Nutrition, Physical Activity, and Metabolism. Circulation. 2006;113:898–918. - PubMed
    1. Perri MG, Corsica JA. Improving the maintenance of weight lost in behavioral treatment of obesity. In: Wadden T, Stunkard AJ, editors. Handbook of Obesity Treatment. The Guilford Press; New York: 2002. pp. 357–379.
    1. Wing RR. Behavioral Weight Control. In: Wadden TA, Stunkard AJ, editors. Handbook of Obesity Treatment. The Guilford Press; New York: 2002. pp. 301–316.
    1. National Institutes of Health Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults - The Evidence Report. Obes. Res. 1998;6(suppl.2) - PubMed

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