doi: 10.1016/j.fitote.2008.06.007.
Epub 2008 Jul 11.
Cytotoxic activity screening of some indigenous Thai plants
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- PMID: 18664377
- DOI: 10.1016/j.fitote.2008.06.007
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Cytotoxic activity screening of some indigenous Thai plants
Fitoterapia.
2008 Dec.
Abstract
The 50% ethanolic extracts from 14 plant species used in Thai traditional folklore were screened for cytotoxic activity against a malignant human hepatoma (HepG2) cell line and a normal African green monkey kidney (Vero) cell line. The extracts of Polyalthia evecta and Erythroxylum cuneatum showed potent anticancer activity in the HepG2 cell line with IC(50) of 70+/-3 microg/ml and 64+/-4 microg/ml, respectively. P. evecta demonstrated more selectivity to the HepG2 than the Vero cell (selectivity index>14.3) indicating its potential for biopharmaceutical use.
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