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. 2008 Jul 21;14(27):4338-41.
doi: 10.3748/wjg.14.4338.

Univariate and multivariate analysis of risk factors for severe Clostridium difficile-associated diarrhoea: importance of co-morbidity and serum C-reactive protein

Christian Hardt  1 , Thomas Berns, Wolfgang Treder, Franz-Ludwig Dumoulin
Affiliations

Univariate and multivariate analysis of risk factors for severe Clostridium difficile-associated diarrhoea: importance of co-morbidity and serum C-reactive protein

Christian Hardt et al. World J Gastroenterol. .

Abstract

Aim: To investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients.

Methods: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review.

Results: Severe CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, P < 0.001) and a higher proportion of longer hospital stay exceeding 14 d (74% vs 52%, P = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, P < 0.05) and serum C-reactive protein at diagnosis (OR 1.15 for 10 mg/L increment, P < 0.001) were independent predictors of severe CDAD.

Conclusion: Patients with a severe level of co-morbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention.

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References

    1. Loo VG, Libman MD, Miller MA, Bourgault AM, Frenette CH, Kelly M, Michaud S, Nguyen T, Poirier L, Vibien A, et al. Clostridium difficile: a formidable foe. CMAJ. 2004;171:47–48. - PMC - PubMed
    1. Bartlett JG. Narrative review: the new epidemic of Clostridium difficile-associated enteric disease. Ann Intern Med. 2006;145:758–764. - PubMed
    1. Aslam S, Musher DM. An update on diagnosis, treatment, and prevention of Clostridium difficile-associated disease. Gastroenterol Clin North Am. 2006;35:315–335. - PubMed
    1. McFarland LV. Diarrhoea associated with antibiotic use. BMJ. 2007;335:54–55. - PMC - PubMed
    1. McFarland LV. Update on the changing epidemiology of Clostridium difficile-associated disease. Nat Clin Pract Gastroenterol Hepatol. 2008;5:40–48. - PubMed

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