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. 2008 Aug;170(2):149-55.
doi: 10.1667/RR1422.1.

Increased frequency of chromosome translocations associated with diagnostic x-ray examinations

Parveen Bhatti  1 , Michele M Doody, Dale L Preston, Diane Kampa, Elaine Ron, Robert W Weinstock, Steven Simon, Alan A Edwards, Alice J Sigurdson
Affiliations

Increased frequency of chromosome translocations associated with diagnostic x-ray examinations

Parveen Bhatti et al. Radiat Res. 2008 Aug.

Abstract

Informative studies of cancer risks associated with medical radiation are difficult to conduct owing to low radiation doses, poor recall of diagnostic X rays, and long intervals before cancers occur. Chromosome aberrations have been associated with increased cancer risk and translocations are a known radiation biomarker. Seventy-nine U.S. radiologic technologists were selected for blood collection, and translocations were enumerated by whole chromosome painting. We developed a dose score to the red bone marrow for medical radiation exposure from X-ray examinations reported by the technologists that they received as patients. Using Poisson regression, we analyzed translocations in relation to the dose scores. Each dose score unit approximated 1 mGy. The estimated mean cumulative red bone marrow radiation dose score was 42 (range 1-265). After adjustment for age, occupational radiation, and radiotherapy for benign conditions, translocation frequencies significantly increased with increasing red bone marrow dose score with an estimate of 0.007 translocations per 100 CEs per score unit (95% CI, 0.002 to 0.013; P = 0.01). Chromosome damage has been linked with elevated cancer risk, and we found that cumulative radiation exposure from medical X-ray examinations was associated with increased numbers of chromosome translocations.

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Figures

FIG. 1
FIG. 1
Translocation frequency as a function of the cumulative diagnostic red bone marrow radiation dose score among 79 U.S. radiologic technologists. The trend line is from univariate Poisson regression analysis [0.013 translocations/100 cell equivalents (CEs)/red bone marrow dose score].
See this image and copyright information in PMC

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