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. 2008 Oct;46(10):3517-21.
doi: 10.1128/JCM.00641-08. Epub 2008 Jul 30.

Dynamics and determinants of Staphylococcus aureus carriage in infancy: the Generation R Study

Ankie Lebon  1 , Joost A M Labout, Henri A Verbrugh, Vincent W V Jaddoe, Albert Hofman, Willem van Wamel, Henriette A Moll, Alex van Belkum
Affiliations

Dynamics and determinants of Staphylococcus aureus carriage in infancy: the Generation R Study

Ankie Lebon et al. J Clin Microbiol. 2008 Oct.

Erratum in

  • J Clin Microbiol. 2010 May;48(5):1995-6

Abstract

Serial nasal swabs were collected at the ages of 1.5, 6, and 14 months from 443 infants in the Generation R Study. The objective was to study the dynamics and determinants of Staphylococcus aureus nasal carriage in the first year of life. The prevalence of S. aureus carriage decreased in the first year of life, from 52.1% at the age of 1.5 months to 12.9% at 14 months. Persistent carriage, defined as continuous carriage of the same S. aureus strain at the three sampling moments, was rarely detected in early infancy.

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Figures

FIG. 1.
FIG. 1.
S. aureus carriage in the first year of life. We found a significant decrease in S. aureus nasal carriage in the first year of life. The P value is <0.001 for the difference between S. aureus carriage rates at 1.5, 6, and 14 months of age.
FIG. 2.
FIG. 2.
S. aureus dendrogram. PFGE analysis was performed for all strains derived from infants with two or more cultures that tested positive for S. aureus. The banding patterns are shown in the central portion of the figure. On the left, the percentage of strain relatedness is indicated in the form of a BioNumerics-generated dendrogram. A cut-off percentage of 90% (vertical solid line) is used to identify similar to identical strains. Strains meeting this criterion and derived from the same infant are indicated by boxing in the right column, which identifies children by study number and by the first (a), second (b), and third (c) culture moment. In three cases, the strains isolated at the three culture moments were identical (arrow).
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