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. 2008 Jun;61(6):400-2.
doi: 10.1038/ja.2008.56.

The binding of antibiotics to ERp57/GRP58

Elisa Gaucci  1 , Silvia Chichiarelli, Caterina Grillo, Emiliana Del Vecchio, Margherita Eufemi, Carlo Turano
Affiliations

The binding of antibiotics to ERp57/GRP58

Elisa Gaucci et al. J Antibiot (Tokyo). 2008 Jun.

Abstract

The effects of five antibiotics, previously described as ligands of protein disulfide isomerase PDI, have now been studied on the homologous protein ERp57. They bind to this protein with much higher affinity than to PDI, and some of them inhibit the reductase and the DNA-binding activities of ERp57. In view of the high affinity of vancomycin, erythromycin and streptomycin, some effects of their interaction with this protein might be expected in vivo.

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