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Editorial
. 2008;12(4):168.
doi: 10.1186/cc6944. Epub 2008 Jul 17.

High mobility group box-1 protein--one step closer to the clinic?

Tom Eirik Mollnes
Editorial

High mobility group box-1 protein--one step closer to the clinic?

Tom Eirik Mollnes. Crit Care. 2008.

Abstract

High mobility group box (HMGB)1, originally described as a nuclear protein that binds to and modifies DNA, is now regarded as a central mediator of inflammation by acting as a cytokine. HMGB1 is postulated to be particularly important as a late acting mediator of lethal septicaemia in mice. Furthermore, it has been suggested that HMGB1 plays a role in clinical conditions such as autoimmunity, acute ischaemia-reperfusion injury, cardiovascular disease and cancer. HMGB1 has emerged as a candidate for therapeutic intervention in various disease conditions. However, further basic and clinical studies are warranted to confirm the roles played by HMGB1 in clinical medicine.

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