Assembly of F0 in Saccharomyces cerevisiae
- PMID: 18672007
- PMCID: PMC2633655
- DOI: 10.1016/j.bbamcr.2008.07.001
Assembly of F0 in Saccharomyces cerevisiae
Abstract
Respiratory deficient mutants of Saccharomyces cerevisiae have been instrumental in identifying an increasing number of nuclear gene products that promote pre- and post-translational steps of the pathway responsible for biogenesis of the mitochondrial ATP synthase. In this article we have attempted to marshal current information about the functions of such accessory factors and the roles they play in expression and assembly of the mitochondrially encoded subunits of the ATP synthase. We also discuss evidence that the ATP synthase may be built up from three separate modules corresponding to the F1 ATPase, the stator and F0.
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References
-
- Boyer PD. The binding change mechanism for ATP synthase--some probabilities and possibilities. Biochim Biophys Acta. 1993;1140:215–250. - PubMed
-
- Boyer PD. The ATP synthase--a splendid molecular machine. Annu Rev Biochem. 1997;66:717–749. - PubMed
-
- Walker JE, Dickson VK. The peripheral stalk of the mitochondrial ATP synthase. Biochim Biophys Acta. 2006;1757:286–296. - PubMed
-
- Walker JE, Fearnley IM, Gay NJ, Gibson BW, Northrop FD, Powell SJ, Runswick MJ, Saraste M, Tybulewicz VL. Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria. J Mol Biol. 1985;184:677–701. - PubMed
-
- Stock D, Leslie AG, Walker JE. Molecular architecture of the rotary motor in ATP synthase. Science. 1999;286:1700–1705. - PubMed
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