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. 2008 Nov;146(5):741-6.
doi: 10.1016/j.ajo.2008.05.048. Epub 2008 Jul 30.

Intraocular pressure, central corneal thickness, and prevalence of open-angle glaucoma: the Los Angeles Latino Eye Study

Brian A Francis  1 , Rohit Varma, Vikas Chopra, Mei-Ying Lai, Corina Shtir, Stanley P Azen; Los Angeles Latino Eye Study Group
Collaborators, Affiliations

Intraocular pressure, central corneal thickness, and prevalence of open-angle glaucoma: the Los Angeles Latino Eye Study

Brian A Francis et al. Am J Ophthalmol. 2008 Nov.

Abstract

Purpose: To examine the relationship between the prevalence of open-angle glaucoma (OAG) and intraocular pressure (IOP) and the impact of central corneal thickness (CCT) on this relationship.

Design: Population-based cross-sectional study.

Methods: The study cohort consisted of 5,970 participants from the Los Angeles Latino Eye Study (LALES) with no history of glaucoma treatment and with complete ophthalmic examination data. The relationship between the prevalence of OAG and IOP was contrasted across persons with CCT designated as thin, normal, or thick.

Results: Prevalence of OAG was exponentially related to IOP. When stratified by CCT, persons with thin CCT had a significantly higher prevalence of OAG than did those with normal or thick CCTs at all levels of IOP. Adjusting each IOP individually for CCT did not impact significantly the relationship between the prevalence of OAG and IOP.

Conclusions: These findings suggest that adjusting for the impact of CCT on IOP by correction algorithms is not necessary in a population based assessment of glaucoma prevalence; CCT, however, is an important independent risk factor for the prevalence of OAG.

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Figures

Figure 1
Figure 1
Relationship between the prevalence of open-angle glaucoma and uncorrected intraocular pressure (IOP) stratified by central corneal thickness (CCT) in microns in the Los Angeles Latino Eye Study.
Figure 2
Figure 2
Lowess curve for relationship between prevalence of open-angle glaucoma and intraocular pressure (IOP) using unadjusted Goldmann tonometry data in the Los Angeles Latino Eye Study. Since we are interested in the IOP levels for which we observe an increase in prevalence of OAG, we take into account positive slope values for determining turning points.
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