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. 2009 May;91(5):1686-91.
doi: 10.1016/j.fertnstert.2008.02.121. Epub 2008 Jul 30.

Reduced expression of biomarkers associated with the implantation window in women with endometriosis

Qingxiang Wei  1 , J Benjamin St Clair, Teresa Fu, Pamela Stratton, Lynnette K Nieman
Affiliations

Reduced expression of biomarkers associated with the implantation window in women with endometriosis

Qingxiang Wei et al. Fertil Steril. 2009 May.

Abstract

Objective: To evaluate the expression of biomarkers of implantation, glycodelin A (GdA), osteopontin (OPN), lysophosphatidic acid receptor 3 (LPA3), and HOXA10, in eutopic endometrium of women with and without endometriosis.

Design: Prospective observational study.

Setting: Clinical research center.

Patient(s): Twenty-four women with endometriosis and 23 healthy volunteers of similar age.

Intervention(s): Secretory phase endometrial biopsy.

Main outcome measure(s): Expression of immunohistochemical staining intensity and localization of GdA, OPN, LPA3, and HOXA10 in eutopic endometrium.

Result(s): Endometrial GdA expression was significantly reduced in patients after cycle day 22. The endometrium from women with endometriosis also showed decreased expression of OPN in the late secretory phase and LPA3 and HOXA10 expression in the midsecretory and late secretory phases.

Conclusion(s): The decreased expression of these four biomarkers of implantation may indicate impaired endometrial receptivity in patients with endometriosis, providing one explanation for the subfertility observed even in women with few pelvic implants. Because many of these markers are P dependent, these findings suggest the possibility of reduced endometrial P action in this population.

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Conflict of interest statement

Conflict of interest: None

Figures

Fig 1
Fig 1
HSCOREs of biomarker expression in glandular epithelium or stroma (S, HOXA10 only) of healthy volunteers (blue bars) and women with endometriosis (red bars) during the early, mid- and late secretory phase (ES, MS, LS, respectively). * indicates p < 0.05
Fig 2
Fig 2
IHC localization of GdA, OPN, LPA3 and HOXA10 in the endometrium of healthy women (denoted N) and women with endometriosis (denoted P), during the early, mid- and late secretory phase (denoted ES, MS and LS, respectively). Expression was significantly reduced in endometriosis endometrium of all paired phase samples, except for mid-secretory OPN and GdA.
See this image and copyright information in PMC

References

    1. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril. 2002;77:1148–55. - PubMed
    1. Giudice LC, Telles TL, Lobo S, Kao L. The molecular basis for implantation failure in endometriosis: on the road to discovery. Ann N Y Acad Sci. 2002;955:252–64. discussion 93-5, 396–406. - PubMed
    1. Kao LC, Germeyer A, Tulac S, Lobo S, Yang JP, Taylor RN, et al. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology. 2003;144:2870–81. - PubMed
    1. Burney RO, Talbi S, Hamilton AE, Vo KC, Nyegaard M, Nezhat CR, et al. Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Endocrinology. 2007;148:3814–26. - PubMed
    1. Lessey BA. The use of integrins for the assessment of uterine receptivity. Fertil Steril. 1994;61:812–4. - PubMed

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