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. 2008 Oct;81(2-3):220-4.
doi: 10.1016/j.eplepsyres.2008.05.003. Epub 2008 Jul 30.

APOE epsilon4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy

Jessica S Chapin  1 , Robyn M Busch, Damir Janigro, Michelle Dougherty, Cristiane Q Tilelli, Tara T Lineweaver, Richard I Naugle, Ramon Diaz-Arrastia, Imad M Najm
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APOE epsilon4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy

Jessica S Chapin et al. Epilepsy Res. 2008 Oct.

Abstract

This study examined the relationship between the APOE epsilon4 allele and postictal confusion in patients with medically intractable temporal lobe epilepsy (TLE). Patients with at least one epsilon4 allele (n=22) were three times more likely to exhibit postictal confusion (68%) than the 63 patients without epsilon4 (43%). These preliminary results demonstrate that APOE epsilon4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms.

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