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Review
. 2008 Aug;66 Suppl 1(Suppl 1):S65-8.
doi: 10.1111/j.1753-4887.2008.00071.x.

The Bmi-1 polycomb group gene in skin cancer: regulation of function by (-)-epigallocatechin-3-gallate

Sivaprakasam Balasubramanian  1 , Kathy Lee, Gautam Adhikary, Ramamurthy Gopalakrishnan, Ellen A Rorke, Richard L Eckert
Affiliations
Review

The Bmi-1 polycomb group gene in skin cancer: regulation of function by (-)-epigallocatechin-3-gallate

Sivaprakasam Balasubramanian et al. Nutr Rev. 2008 Aug.
No abstract available

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Figures

Figure 1
Figure 1. Chemopreventive agent action is mediated by the Bmi-1 epigenetic regulator
Bmi-1 is present at elevated levels in skin tumor cells, where it functions to enhance cell survival by increasing cell proliferation and suppressing apoptosis (mediated via effects on both cell cycle and apoptotic regulators). Treatment with the chemopreventive agent EGCG causes a reduction in the Bmi-1 level. This negatively impacts cell number by reducing the tendency of the cells to proliferate and by enhancing their tendency to undergo apoptosis. This model proposes that the Bmi-1 epigenetic regulator mediates some of the chemopreventive effects of EGCG.
See this image and copyright information in PMC

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