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Review
. 2009 Apr-May;45(4-5):335-9.
doi: 10.1016/j.oraloncology.2008.05.015. Epub 2008 Jul 31.

Molecular techniques and genetic alterations in head and neck cancer

Patrick K Ha  1 , Steven S Chang, Chad A Glazer, Joseph A Califano, David Sidransky
Affiliations
Review

Molecular techniques and genetic alterations in head and neck cancer

Patrick K Ha et al. Oral Oncol. 2009 Apr-May.

Abstract

It is well known that cellular DNA alterations can lead to the formation of cancer, and there has been much discovery in the pathways involved in the development of head and neck squamous cell carcinoma (HNSCC). With novel genome-wide molecular assays, our ability to detect these abnormalities has increased. We now have a better understanding of the molecular complexity of HNSCC, but there is still much research to be done. In this review, we discuss the well described genetic alterations and touch on the newer findings, as well as some of the future directions of head and neck cancer research.

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Conflict of interest statement

Conflict of Interest Statement: None of the authors have any actual or potential conflict of interest including any financial, personal or other relationships with people or organizations that could inappropriately influence (bias) this work.

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