Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Sep;31(9):464-8.
doi: 10.1016/j.tins.2008.06.006. Epub 2008 Jul 31.

The HPA axis in major depression: classical theories and new developments

Carmine M Pariante  1 , Stafford L Lightman
Affiliations
Review

The HPA axis in major depression: classical theories and new developments

Carmine M Pariante et al. Trends Neurosci. 2008 Sep.

Abstract

Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources