Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Sep 3;582(20):2985-92.
doi: 10.1016/j.febslet.2008.07.046. Epub 2008 Aug 7.

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

Lucas Bleicher  1 , Patricia Ribeiro de Moura, Leandra Watanabe, Didier Colau, Laure Dumoutier, Jean-Christophe Renauld, Igor Polikarpov
Affiliations
Free article

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

Lucas Bleicher et al. FEBS Lett. .
Free article

Abstract

Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2.

PubMed Disclaimer

Publication types