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Review
. 2009;56 Suppl 1(Suppl 1):169-73.
doi: 10.1016/j.neuropharm.2008.07.011. Epub 2008 Jul 16.

Glutamate transmission in addiction

Peter W Kalivas  1 , Ryan T Lalumiere, Lori Knackstedt, Haowei Shen
Affiliations
Review

Glutamate transmission in addiction

Peter W Kalivas et al. Neuropharmacology. 2009.

Abstract

Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locomotor sensitization and drug-seeking. While glutamate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction.

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References

    1. Abraham WC. Metaplasticity: tuning synapses and networks for plasticity. Nat Rev Neurosci. 2008;9:387–399. - PubMed
    1. Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE, Terwilliger EF, Cha JH, Pierce RC. CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nat Neurosci. 2008;11:344–353. - PubMed
    1. Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, Kalivas PW. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci. 2003;6:743–749. - PubMed
    1. Baptista MA, Martin-Fardon R, Weiss F. Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. J Neurosci. 2004;24:4723–4727. - PMC - PubMed
    1. Berridge K, Robinson T. What is the role of dopamine in reward: hedonic impact,reward learning, or incentive salience? Brain Research Reviews. 1998;28:309–369. - PubMed

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