doi: 10.1016/j.bmc.2008.07.032.
Epub 2008 Jul 20.
Synthesis and antimicrobial activity of dermaseptin S1 analogues
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- PMID: 18676150
- DOI: 10.1016/j.bmc.2008.07.032
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Synthesis and antimicrobial activity of dermaseptin S1 analogues
Bioorg Med Chem.
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Free article
Abstract
Dermaseptins are peptides found in the skin secretions of Phyllomedusinae frogs. These peptides exert lytic action on some microorganisms without substantial haemolysis. In an attempt to understand the antimicrobial activity of these peptides we designed several dermaseptin S1 (ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ) (DS1) analogues. All peptides were tested on the growth of prokaryotic (Gram-positive and Gram-negative bacteria) and eukaryotic (the yeast Candida albicans and the protozoon Leishmania major) organisms. Our data showed a dose-dependent killing effect by most DS1 derivatives. Maximal antibacterial activity was displayed by a 16-mer peptide that was more active than native DS1.
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