doi: 10.1073/pnas.73.11.3872.
DNA gyrase: an enzyme that introduces superhelical turns into DNA
- PMID: 186775
- PMCID: PMC431247
- DOI: 10.1073/pnas.73.11.3872
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DNA gyrase: an enzyme that introduces superhelical turns into DNA
Proc Natl Acad Sci U S A.
1976 Nov.
Abstract
Relaxed closed-circular DNA is converted to negatively supercoiled DNA by DNA gyrase. This enzyme has been purified from Escherichia coli cells. The reaction requires ATP and Mg++ and is stimulated by spermidine. The enzyme acts equally well on relaxed closed-circular colicin E1, phage lambda, and simian virus 40 DNA. The final superhelix density of the DNA can be considerably greater than that found in intracellularly supercoiled DNA.
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