Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Nov;73(11):4065-9.
doi: 10.1073/pnas.73.11.4065.

Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus

E Wang, A R Goldberg

Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus

E Wang et al. Proc Natl Acad Sci U S A. 1976 Nov.

Abstract

A series of morphological changes occurred when chick embryo fibroblasts infected with the NY68 mutant of Rous sarcoma virus were shifted from nonpermissive temperature (41degrees) to permissive temperature (37 degrees). We observed three distinct stages in cell morphology and surface topography that were correlated with a reduction in the organization and assembly of actin-containing microfilament bundles. Our observations suggest that control of microfilament organization and surface topography are responsive to the presence of a functioning transforming gene (src) product of Rous sarcoma virus.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1974 Jun;71(6):2268-72 - PubMed
    1. Proc Natl Acad Sci U S A. 1969 Jun;63(2):318-25 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Dec;67(4):1673-80 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Jan;68(1):244-7 - PubMed
    1. J Cell Biol. 1971 Sep;50(3):691-708 - PubMed

Publication types

MeSH terms

LinkOut - more resources