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Comparative Study
. 2009 Sep 11;137(1):81-3.
doi: 10.1016/j.ijcard.2008.05.017. Epub 2008 Aug 3.

Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure

Guy D Eslick, Binu V Thampan, Marek Nalos, Anthony S McLean, Ronald Sluyter
Comparative Study

Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure

Guy D Eslick et al. Int J Cardiol. .

Abstract

We examined if a loss-of-function polymorphism in the P2X(7) receptor (1513C) corresponded with circulating interleukin(IL)-18 concentrations in heart failure (HF) patients. IL-18 values were significantly elevated in HF subjects compared to healthy control subjects. No association was seen between the polymorphism and IL-18 concentrations in HF patients. In HF patients, IL-18 values had an inverse relationship with ejection fraction, mean arterial pressure and body mass index, while high IL-18 concentrations were associated with increased mortality.

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