Comes a time

Abstract

The circadian clock is a selfsustaining oscillator with an endogenous period of approximately 24 hours. The Arabidopsis clock is composed of a set of interlocking negative feedback loops entailing transcriptional, post-transcriptional, and post-translational, particularly regulated proteolysis, control. Clock control of the transcriptome is widespread; up to 90% of the transcriptome cycles in at least one condition in seedlings exposed to a variety of environmental cycles. Clock control extends to the metabolome, though diurnal oscillations in enzyme activities and metabolites are less dramatic than oscillations in cognate transcripts. Metabolites, including organic nitrogen intermediates, feed back to modulate clock function, consistent with the view of the circadian clock as a key integrator of metabolic signals to coordinate metabolism and physiology with the environment.