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. 1976 Nov;73(11):4169-73.
doi: 10.1073/pnas.73.11.4169.

Localization of gene functions in polyoma virus DNA

J Feunteun, L Sompayrac, M Fluck, T Benjamin

Localization of gene functions in polyoma virus DNA

J Feunteun et al. Proc Natl Acad Sci U S A. 1976 Nov.

Abstract

Polyoma virus mutants of four functionally distinct groups have been mapped by the marker rescue technique using restriction enzyme fragments of wild-type viral DNA. Nontransforming host-range mutants map in the proximal part of the early region of the viral genome. The same DNA fragment that restores a normal host range also restores normal transforming ability to these mutants. ts-25D, a temperature-sensitive (ts)-a class mutant, maps in the distal part of the early region. ts-3 and ts-1260 map in the proximal and distal parts of the late region, respectively.

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References

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