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Case Reports
. 2008 Jul 28;14(28):4576-9.
doi: 10.3748/wjg.14.4576.

Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis

Gudrun Scheving Thorsteinsson  1 , Maria Magnussson, Lena M Hallberg, Nils Gunnar Wahlgren, Fredrik Lindgren, Petter Malmborg, Thomas H Casswall
Affiliations
Case Reports

Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis

Gudrun Scheving Thorsteinsson et al. World J Gastroenterol. .

Abstract

The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor X.

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Figures

Figure 1
Figure 1
T1 contrast enhanced transverse image showing a focal dark area (arrow) in the right transverse sinus and confluence, which are consistent with a cerebral sinus thrombosis.
Figure 2
Figure 2
Platelet count expressed in 109/L blood (normal range, 125-340) from readmission until discharge showing the progress of thrombocytopenia. The letters denote start or end of heparin (Hs and He), fondaparinux (Fs and Fe), warfarin (Ws), and azatioprine (Ae and As). W1 denotes only one dose. Dotted line denotes a level of thrombocytes lower than their normal range.
See this image and copyright information in PMC

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