Can a topical microbicide prevent rectal HIV transmission?
- PMID: 18684009
- PMCID: PMC2494564
- DOI: 10.1371/journal.pmed.0050167
Can a topical microbicide prevent rectal HIV transmission?
Abstract
Florian Hladik and Charlene Dezzutti discuss a macaque study of whether rectal simian immunodeficiency virus transmission can be prevented by topical pre-exposure application of tenofovir gel.
Conflict of interest statement
Comment on
-
Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.PLoS Med. 2008 Aug 5;5(8):e157; discussion e157. doi: 10.1371/journal.pmed.0050157. PLoS Med. 2008. PMID: 18684007 Free PMC article.
References
-
- Cohen J. AIDS research. Microbicide fails to protect against HIV. Science. 2008;319:1026–1027. - PubMed
-
- van de Wijgert JH, Shattock RJ. Vaginal microbicides: moving ahead after an unexpected setback. AIDS. 2007;21:2369–2376. - PubMed
-
- García-Lerma JG, Otten RA, Qari SH, Jackson E, Cong Me, et al. Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir. PLoS Med. 2008;5:e28. doi: 10.1371/journal.pmed.0050028. - DOI - PMC - PubMed
-
- Denton PW, Estes JD, Sun Z, Othieno FA, Wei BL, et al. Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med. 2008;5:e16. doi: 10.1371/journal.pmed.0050016. - DOI - PMC - PubMed
-
- Cranage M, Sharpe S, Herrera C, Cope A, Dennis M, et al. Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel. PLoS Med. 2008;5:e157. doi: 10.1371/journal.pmed.0050157. - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical