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Comment
. 2008 Aug 5;5(8):e167.
doi: 10.1371/journal.pmed.0050167.

Can a topical microbicide prevent rectal HIV transmission?

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Comment

Can a topical microbicide prevent rectal HIV transmission?

Florian Hladik et al. PLoS Med. .

Abstract

Florian Hladik and Charlene Dezzutti discuss a macaque study of whether rectal simian immunodeficiency virus transmission can be prevented by topical pre-exposure application of tenofovir gel.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Comment on

References

    1. Cohen J. AIDS research. Microbicide fails to protect against HIV. Science. 2008;319:1026–1027. - PubMed
    1. van de Wijgert JH, Shattock RJ. Vaginal microbicides: moving ahead after an unexpected setback. AIDS. 2007;21:2369–2376. - PubMed
    1. García-Lerma JG, Otten RA, Qari SH, Jackson E, Cong Me, et al. Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir. PLoS Med. 2008;5:e28. doi: 10.1371/journal.pmed.0050028. - DOI - PMC - PubMed
    1. Denton PW, Estes JD, Sun Z, Othieno FA, Wei BL, et al. Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med. 2008;5:e16. doi: 10.1371/journal.pmed.0050016. - DOI - PMC - PubMed
    1. Cranage M, Sharpe S, Herrera C, Cope A, Dennis M, et al. Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel. PLoS Med. 2008;5:e157. doi: 10.1371/journal.pmed.0050157. - DOI - PMC - PubMed

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