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Review
. 2008 Aug 15;5(6):695-8.
doi: 10.1513/pats.200801-011AW.

Hierarchical organization of lung progenitor cells: is there an adult lung tissue stem cell?

Barry R Stripp  1
Affiliations
Review

Hierarchical organization of lung progenitor cells: is there an adult lung tissue stem cell?

Barry R Stripp. Proc Am Thorac Soc. .

Abstract

Dynamic changes to the developing lung endoderm during the process of lung development result in the establishment of functionally distinct epithelial compartments that vary both in their cellular composition and mechanisms contributing to their maintenance in adulthood. This focused review compares the hierarchical organization of cells within slowly and rapidly renewing tissues as a basis to better understand cellular and molecular mechanisms regulating epithelial maintenance and repair in the lung.

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Figures

Figure 1.
Figure 1.
Hierarchical organization of progenitor cells and their differentiated progeny within rapidly (classical stem cell hierarchy; left) and slowly (nonclassical stem cell hierarchy; right) renewing tissues. S, adult tissue stem cell; TA, transit-amplifying cell; TD, terminally differentiated cells.
See this image and copyright information in PMC

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