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Abstract

A plan to ‘genomicize’ epigenomics research and pave the way for breakthroughs in the prevention, diagnosis and treatment of human disease.

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Figures

Figure 1 |
Figure 1 |. Epigenetic mechanisms.
The coding and structural information in the base sequence of DNA is organized in chromatin to form multiple epigenomes. DNA cytosine methylation and covalent modifications of the tails of histones and histone variants contribute information to nucleosomal remodelling machines that render genes and non-coding RNAs susceptible to transcription. Transcription factors (not shown) also play a major part in the competence and organization of the epigenome. The AHEAD project will map epigenetic marks in a defined set of epigenomes.
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References

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