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. 1991 Mar;19(3):235-7.
doi: 10.1007/BF00336492.

Chromosome rearrangements in improved cephalosporin C-producing strains of Acremonium chrysogenum

A W Smith  1 , K Collis, M Ramsden, H M Fox, J F Peberdy
Affiliations

Chromosome rearrangements in improved cephalosporin C-producing strains of Acremonium chrysogenum

A W Smith et al. Curr Genet. 1991 Mar.

Abstract

A number of A. chrysogenum strains from a lineage improved in cephalosporin C production were analysed by contoured-clamped homogeneous electric field gel electrophoresis (CHEF). Although antibiotic titre was increased across the lineage, chromosome rearrangements were only observed at two points in it. In one member of the lineage the chromosomal changes included those which altered the size of the chromosome on which the isopenicillin N synthetase gene (pcbC) was located. It is proposed that chromosome changes are a chance event in an industrial strain improvement programme.

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References

    1. Curr Genet. 1989 Dec;16(5-6):453-9 - PubMed
    1. Gene. 1989 May 30;78(2):331-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6260-3 - PubMed
    1. J Gen Microbiol. 1985 Oct;131(10):2813-23 - PubMed
    1. Curr Genet. 1987;12(5):337-48 - PubMed

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