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Review
. 2008;3(2):169-80.
doi: 10.2147/ijn.s1608.

Magnetic nanoparticles for gene and drug delivery

Stuart C McBain  1 , Humphrey H P Yiu, Jon Dobson
Affiliations
Review

Magnetic nanoparticles for gene and drug delivery

Stuart C McBain et al. Int J Nanomedicine. 2008.

Abstract

Investigations of magnetic micro- and nanoparticles for targeted drug delivery began over 30 years ago. Since that time, major progress has been made in particle design and synthesis techniques, however, very few clinical trials have taken place. Here we review advances in magnetic nanoparticle design, in vitro and animal experiments with magnetic nanoparticle-based drug and gene delivery, and clinical trials of drug targeting.

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Figures

Figure 1
Figure 1
A typical design of a magnetic nanoparticle for biotechnology.
Figure 2
Figure 2
Illustration explaining the use of the reverse micelle mechanism in synthesizing magnetic nanoparticles.
Figure 3
Figure 3
The structure of PVA (a) which is compared with a polysaccharide (b) as both materials have abundant hydroxyl groups on surface. The crosslinking reaction is shown in (c).
Figure 4
Figure 4
Silylation of a silica surface using triethoxysilane.
Figure 5
Figure 5
Illustration of the use of thiol linkers for binding biomolecules onto gold coated magnetic nanoparticles.
See this image and copyright information in PMC

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