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Review
. 2008 Aug;34(3):623-43.
doi: 10.1016/j.rdc.2008.05.004.

The symptoms of osteoarthritis and the genesis of pain

David J Hunter  1 , Jason J McDougall, Francis J Keefe
Affiliations
Review

The symptoms of osteoarthritis and the genesis of pain

David J Hunter et al. Rheum Dis Clin North Am. 2008 Aug.

Abstract

Symptomatic osteoarthritis (OA) causes substantial physical and psychosocial disability. This article delineates the characteristic symptoms and signs associated with OA and how they can be used to make the clinical diagnosis. The predominant symptom in most patients is pain. The remainder of the article focuses on what is known about the causes of pain in OA and factors that contribute to its severity. Much has been learned during recent years, but much of this puzzle remains unexplored or inadequately understood.

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Figures

Figure 1
Figure 1
Future Targets to Control Osteoarthritis Pain (insert legend embedded in bottom of figure) From Arthritis Research & Therapy 2007, 9:212 (doi:10.1186/ar2178)
Figure 2
Figure 2
Pain transmission. Reproduced with permission from Schaible H-G et al. (44)
See this image and copyright information in PMC

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