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Editorial
. 2008 Sep;64(3):232-6.
doi: 10.1002/ana.21466.

Neonatal encephalitis and white matter injury: more than just inflammation?

Joseph J Volpe
Editorial

Neonatal encephalitis and white matter injury: more than just inflammation?

Joseph J Volpe. Ann Neurol. 2008 Sep.
No abstract available

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Figures

Figure
Figure
Potential role of toll-like receptors (TLR) in pathogenesis of white matter injury with HPeV3 encephalitis. HPeV3, a small single-stranded (ss) RNA virus, is taken up by brain microglia and the organism’s released ssRNA binds to intracellular TLR 8 to initiate the innate immune response. The resulting release of reactive oxygen and nitrogen species and proinflammatory cytokines would lead to pre-oligodendrocyte (Pre-OL) and axonal injury. Additionally the ssRNA of HPeV3, after infecting the neuron, could activate TLR 8 in the cell body but especially in the developing axon and growth cone (where TLR 8 is most abundant). The result would be axonal retraction and neuronal apoptosis (see text for details).
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References

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