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Randomized Controlled Trial
. 2008 Apr;27(2):274-9.
doi: 10.1080/07315724.2008.10719700.

Body size and serum 25 hydroxy vitamin D response to oral supplements in healthy older adults

Miriam Blum  1 , Gerard E Dallal, Bess Dawson-Hughes
Affiliations
Randomized Controlled Trial

Body size and serum 25 hydroxy vitamin D response to oral supplements in healthy older adults

Miriam Blum et al. J Am Coll Nutr. 2008 Apr.

Abstract

Background: Vitamin D insufficiency is prevalent in the northeast United States. Since vitamin D insufficiency is readily amenable to supplementation, it is important to understand what factors are associated with serum 25 hydroxy vitamin D (25(OH)D) response to vitamin D supplementation.

Objective: In this study we examined the association of serum 25(OH)D response to vitamin D supplementation with body size in a population of elderly subjects.

Methods: 257 healthy, ambulatory men and women 65 years of age or older were randomly assigned to treatment with either 700 IU/day (17.5 microg/d) of supplemental vitamin D(3) and 500 mg/day (12.5 mmol/d) of supplemental calcium, or to placebo.

Results: In multivariate regression analyses, after adjusting for baseline 25(OH)D, season, and sex, we found change in 25(OH)D to be inversely associated with baseline BMI (p = 0.01) in subjects treated with supplements for one year. Change in 25(OH)D was also negatively associated with other baseline anthropometric measurements in these subjects.

Conclusion: Our study implies that body size should be taken into account when estimating the amount of vitamin D intake needed to raise 25(OH)D to the desired level.

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Figures

Figure 1
Figure 1
Mean adjusted change in 25(OH)D level (±SEM) at one year in the calcium-vitamin D and placebo groups, each divided into subgroups based on BMI at baseline. (Subgroup I: BMI < 25 kg/m2, subgroup II: 25 kg/m2 ≤ BMI< 30 kg/m2, subgroup III: BMI ≥30 kg/m2 ). Mean change in 25(OH)D level for calcium-vitamin D BMI subgroups (ANOVA P = 0.05) and placebo BMI subgroups (NS) are each adjusted for baseline 25(OH)D level and season. Sample size for the six groups from left to right are as follows: n= 47, n=46, n=59, n=56, n=26, n=23. *Significantly differs from BMI subgroup I (P < 0.05). To convert values for serum 25(OH)D to nmol/l, multiply by 2.5.
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References

    1. Reichel H, Koeffler H, Norman A. The Role of the vitamin D endocrine system in health and disease. N Engl J Med. 1989;320:981–991. - PubMed
    1. Boucher B. Inadequate vitamin D status: does it contribute to the disorders comprising syndrome 'X'? Br J Nutr. 1998;79:315–327. - PubMed
    1. Sowers MR, Wallace RB, Lemke J. The association of intakes of vitamin D and calcium with blood pressure among women. Am J Clin Nutr. 1985;42:135–142. - PubMed
    1. Pfeifer M, Begerow B, Nachtigall D, Minne H. Vitamin D and calcium supplementation reduces blood pressure and secondary hyperparathyroidism in elderly women: A prospective, randomized, double-blind study. J Bone Miner Res. 1999;15(suppl):S443. - PubMed
    1. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen S. Intake of vitamin D and risk of type I diabetes: A birth-cohort study. Lancet. 2001;358:1500–1503. - PubMed

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